I'll be very interested in your experience with the Tune Boy and the maps you develop. It should be fairly easy to make initial throttle response smooth, however, without an exhaust gas analyzer adjustments at higher rpm would seem to be trial and error.
The oxygen sensor keeps the ECU in a closed loop for a certain range of operation which I've heard is up to 5100 rpm. I'm not sure if the Tune Boy can over-ride this feed back loop.
I love programmable fuel injection systems and began messing with them back in '93 (Haltech from Australia) and the Power Commanders. But the factory TOR tune runs so good, I'm not sure there would be benefits.